4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROCHINOLINE DERIVATIVES AS MEDICATIONS FOR TREATMENT OF INFERTILITY Russian patent published in 2010 - IPC C07D401/12 C07D215/20 A61K31/47 A61K31/4709 A61P5/24 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinoline derivatives of formula 1 , in which R¹ represents (1-6C)alkyl; R² represents halogen; R³ represents SO₂NR⁵R⁶ or (1-4C)alkoxy; X represents O or NR⁷; R⁴ represents R⁸-(2-8C)alkyl, R⁸-(3-8C)alkenyl or R⁸-(2-4C)alkoxy-(2-4C)alkyl; Z represents CN or NO₂; R⁵ and R⁶ independently on each other represent H or (1-4C)alkyl; or R⁵ together with R⁶ and N, to which they are bound, form 5-6-member saturated ring, optionally containing additional heteroatom, selected from O; R⁸ represents OH, (1-4C)alkoxy, NH₂; NR⁹C(O)R¹¹, NR⁹SO₂R¹¹ or C(O)NR⁹R¹⁰; R⁷ and R⁹ independently represent H or (1-4C)alkyl; R¹⁰ represents (1-4C)alkyl; R¹¹ represents (1-4C)alkyl, (1-4C)alkoxy(1-4C)alkyl, (3-6C)cycloalkyl, (1-4C)alkoxy or phenyl, or (4-5C)heteroaryl, and (4-5C)heteroaryl stands for aromatic group, which has 4-5 carbon atoms and at least one heteroatom, selected from N and O; or to their pharmaceutically acceptable salts. Invention also relates to pharmaceutical composition, as well as to application of 2-methyl-4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinoline derivatives.

EFFECT: obtaining novel biologically active compounds, possessing agonistic activity with respect to FSH receptor.

8 cl, 33 ex