TETRAHYDROQUINOLIN DERIVATIVES, BASED PHARMACEUTICAL COMPOSITION BASED ON THEM AND THEIR APPLICATION AS FERTILITY MODULATOR Russian patent published in 2008 - IPC C07D215/38 C07D405/12 C07D409/12 C07D401/12 C07D413/12 C07D409/14 A61K31/47 A61P5/08 

FIELD: chemistry.

SUBSTANCE: invention relates to the tetrahydroquinolin derivatives with the common formula (I) or their pharmaceutically acceptable salts, where R¹ and R² are H or Me; R³ is H, hydroxy or (1-4C)alkoxi; R⁴ is H, OH, (1-4C)alkoxi; R⁵ is OH, (1-4C)alkoxi or R⁷; provided the R⁴ is H, then R⁵ differs from OH or (1-4C)alkoxi; R⁶ is (2-5C)heteroaryl, not necessarily substituted with one or more substitutes, selected from (1-4C)alkyla, bromine or chlorine; (6C)aryl, not necessarily substituted with one or more substitutes, selected from (1-4C)alkyla, (1-4)C-alkoxi, bromine, chlorine, phenyl or (1-4C) (di)alkylamino; (3-8C)cycloalkyl, (2-6C)heterocycloalkyl or (1-6C)-alkyl; R⁷ is amino, (di)(1-4C)alkylamino, (6C)arylcarbonylamino, (2-5C)heteroarylcarbonylamino, (2-5C)heteroaryl-carbonylokxi, R⁸-(2-4C)alkoxi, R⁹-methylamino or R⁹-methoxi; R⁸ is amino, (1-4C)alkoxi, (di)(1-4C)-alkylamino, (2-6C)-heterocycloalkyl, (2-6C)heterocycloalkylcarbonylamino or (1-4C)-alkoxicarbonylamino; and R⁹ is aminocarbonyl, (di)(1-4C)alkylaminocarbonyl, (2-5C)heteroaryl or (6C)aryl. The invention also relates to the pharmaceutical composition which contains the said derivatives, and to the application of the derivatives in fertility modulating.

EFFECT: novel tetrahydroquinolin derivatives with follicle-stimulating hormone receptors modulating activity are obtained.

15 cl, 51 dwg