METHOD OF PRODUCTION OF 5-[(R)-2-(5,6-DIETHYLINDAN-2-YLAMINO)-1-HYDROXYETHYL]-8-HYDROXY-(1H)-QUINOLIN-2-ONE SALT WHICH IS USEFUL AS ADRENORECEPTOR AGONIST Russian patent published in 2008 - IPC C07D215/26 

FIELD: chemistry.

SUBSTANCE: invention relates to the method of 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one salt preparation, it includes: (i) reaction of 8-substituted oxy-5-(R)-oxyranyl-(1H)-quinolin-2-one of formula (I) with 2-amino-(5,6-diethyl)-idan while deriving reaction mixture, which contains the compounds of formula (II) , (III) and (IV) wherein R represents protective group; (ii)-treatment of the reaction mixture derived on stage (I) with acid chosen from the group consisting of benzoic acid, maleic acid, amber acid, fumaric acid, tartaric acid, chlorohydrogen acid with a solvent while deriving corresponded salt; (iii) extraction and crystallization of the salt of formula (V) , wherein R represents a protective group and A^- represents an anion; (iv) removal of the protective group from the salt of formula (V) with the solvent while deriving the salt of formula (VI) , wherein A^- represents an anion; and (v) treatment of the salt of formula (VI) with an acid, selected from the group consisting of benzoic acid, maleic acid, amber acid, fumaric acid, tartaric acid with the solvent while deriving 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one salt of formula (VII) , wherein X^- represents an anion.

EFFECT: creation of the method of 5-[(R)-2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-8-hydroxy-(1H)-quinolin-2-one salt production.

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