FIELD: medicine.
SUBSTANCE: invention concerns experimental medicine, particularly hematology and pharmacology. The claimed method involves registration of absolute quantity of hematosis granulocyte shoot cells - neutrophils - in peripheral blood of experimental animals (mice) after hematosis hypoplasia emulation by a single administration of cytostatic agent in maximum endurable dose (MED) (cyclophosphane or 5-fluorouracil) before and after administration of a substance under test. Reliable criterion of granulocytopenia-stimulating effect of administrated pharmacological substance is increase in neutrophil quantity by 150% or more.
EFFECT: simplification of definition method for granulocytopenia-stimulating effect of pharmacological substances and extension of its applicability.
3 ex, 3 tbl
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