METHOD OF GRANULOCYTOPOIESIS DEPRESSION CORRECTION IN CYTOSTATIC ACTION Russian patent published in 2009 - IPC A61K31/475 A61K38/18 A61P35/00 

Abstract RU 2366422 C1

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to haematology, and concerns correction of granulocytopoiesis depression in cytostatic action. It is ensured by daily single introduction of recombinant human granulocytic colony-stimulating factor (G-CSF) in a dose 100 mkg/kg within 5 days that is preceded with introduction of a cytostatic agent. Herewith, 30 minutes prior to introduction of the cytostatic agent, reserpine dosed 2 mg/kg is introduced.

EFFECT: method provides effective correction of granulocytopoiesis and reduced by-effects of prolonged introduction of G-CSF owing to ability of reserpine introduced in the developed dose and the related schedule to potentiate effect of G-CSF.

9 tbl, 1 ex

Similar patents RU2366422C1

Title Year Author Number
METHOD OF DETERMINING EFFICACY OF HAEMOSTIMULATORS IN CYTOSTATIC MYELOSUPPRESSION 2009
  • Dygaj Aleksandr Mikhajlovich
  • Skurikhin Evgenij Germanovich
  • Pershina Ol'Ga Viktorovna
  • Andreeva Tat'Jana Viktorovna
  • Khmelevskaja Ekaterina Sergeevna
RU2421720C2
METHOD OF MYELOPOIESIS STIMULATION 2008
  • Gol'Dberg Evgenij Danilovich
  • Dygaj Aleksandr Mikhajlovich
  • Zjuz'Kov Gleb Nikolaevich
  • Zhdanov Vadim Vadimovich
RU2366452C1
METHOD OF GRANULOCYTOPENIA-STIMULATING EFFECT EVALUATION FOR PHARMACOLOGICAL SUBSTANCES 2006
  • Gol'Dberg Evgenij Danilovich
  • Dygaj Aleksandr Mikhajlovich
  • Zjuz'Kov Gleb Nikolaevich
  • Zhdanov Vadim Vadimovich
  • Simanina Elena Vladislavna
  • Gur'Jantseva Larisa Arkad'Evna
  • Khrichkova Tat'Jana Jur'Evna
  • Udut Elena Vladimirovna
  • Stavrova Larisa Aleksandrovna
  • Sotnikova Natal'Ja Vladimirovna
RU2332667C1
MEDICATION PREVENTING DEVELOPMENT OF DEPRESSION OF HEMATOPOIESIS ERYTHROID LINEAGE IN CASE OF CYTOSTATIC MYELO DEPRESSIONS 2007
  • Gol'Dberg Evgenij Danilovich
  • Dygaj Aleksandr Mikhajlovich
  • Pershina Ol'Ga Viktorovna
  • Skurikhin Evgenij Germanovich
  • Minakova Marija Jur'Evna
RU2351333C1
METHOD OF MYELOPOIESIS STIMULATION 2007
  • Gol'Dberg Evgenij Danilovich
  • Dygaj Aleksandr Mikhajlovich
  • Zjuz'Kov Gleb Nikolaevich
  • Zhdanov Vadim Vadimovich
RU2336899C1
MEDICINAL AGENT STIMULATING ERYTHROIDE HEMOPOIESIS GERM AT CYTOSTATIC MYELODEPRESSION STATES 1992
  • Gol'Dberg E.D.
  • Dygaj A.M.
  • Khlusov I.A.
  • Aksinenko S.G.
RU2061475C1
MEDICINAL AGENT STIMULATING ERYTHROID AND GRANULOCYTE ERYTHROPOIESIS STEMS AT CYTOSTATIC MYELODEPRESSIONS 1993
  • Gol'Dberg E.D.
  • Dygaj A.M.
  • Khlusov I.A.
  • Aksinenko S.G.
RU2083201C1
DRUG STIMULATING GRANULOCYTE HEMOPOIESIS GRAFT IN CYTOSTATIC MYELODEPRESSION 1999
  • Gol'Dberg E.D.
  • Dygaj A.M.
  • Khlusov I.A.
  • Raskovalova T.Ju.
RU2157688C1
AGENT INTENSIFYING ACTION OF BIOLOGICALLY ACTIVE SUBSTANCES AND DRUGS 2009
  • Artamonov Andrej Vladimirovich
  • Bekarev Andrej Aleksandrovich
  • Vereshchagin Evgenij Ivanovich
  • Dygaj Aleksandr Mikhajlovich
  • Zhdanov Vadim Vadimovich
  • Zjuz'Kov Gleb Nikolaevich
  • Udut Vladimir Vasil'Evich
RU2421239C1
MEDICINE CAPABLE OF SELECTIVELY STIMULATING GRANULO-MONOCYTOPOIESIS IN CASE OF HYPOPLASIA OF MEDULLARY HEMOPOIESIS TRIGGERED BY CYTOSTATIC 1988
  • Gol'Dberg E.D.
  • Dygaj A.M.
  • Karpova G.V.
  • Simanina E.V.
  • Khlusov I.A.
  • Shakhov V.P.
  • Jushkov B.G.
  • Jastrebov A.P.
RU2020936C1

RU 2 366 422 C1

Authors

Gol'Dberg Evgenij Danilovich

Dygaj Aleksandr Mikhajlovich

Pershina Ol'Ga Viktorovna

Skurikhin Evgenij Germanovich

Dates

2009-09-10Published

2008-05-19Filed