FIELD: chemistry.
SUBSTANCE: invention concerns new compounds of the formula (I) 
and their pharmaceutically acceptable salts; where n is an integer independently equal to 1 or 2; X is a halogen; R1 is selected out of a group including hydrogen, carbonyl, sulfonyl, low alkyl and low alkyl substituted for hydroxyl group; R12 is selected out of a group including alkyl and alkenyl containing ca. 1 to 5 carbon atoms, and 
where R7-R11 are independently selected out of a group including hydrogen, halogen, -CN, -NO2, CF3, -OCH3, -COOCH3 and -C6H5; R2-R6 are independently selected out of a group including hydrogen, halogen, low alkyl, -C(CH3)3, CF3, -OCH3, -NO2 and -CN; and if R12 is alkyl or alkenyl containing ca. 1 to 5 carbon atoms then R2-R6 are hydrogen. The invention also concerns pharmaceutical composition.
EFFECT: obtaining new biologically active compounds and pharmaceutical composition based on there, with inhibition effect on MDM2-p53.
29 cl, 97 ex
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