FIELD: chemistry, medicine.
SUBSTANCE: invention relates to novel pyrrolidone derivatives of formula I 
where Q stands for =N- or =C(R24)-; X-Y stands for -CH2-CH2-, -CH=CH-, -CH2-O-; R1, R1.1 and R1.2 independent on each other stand for halogen, C1-C6alkyl, halogen(C1-C6)alkyl, cyano, C1-C6alkoxy, halogen(C1-C6)alkoxy; R21, R22 and R23 independent on each other stand for H and halogen; R24 stands for H, CH3, halogen; R3 stands for -C(O)N(H)CH3, -CH2CN; R4 stands for H; as well as its individual isomers, racemic or non-racemic mixtures of isomers. Compounds inhibit monoaminooxidase, which allows to use them in pharmaceutical compositions for treatment and prevention of Alzheimer's disease and senile dementia.
EFFECT: invention ensures enhancing efficiency of composition and method of treatment.
19 cl, 5 dwg, 49 ex
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