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(19)

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2 335 342

(13)

(51)

IPC

B01J31/24(2006-01-01)

C07F9/50(2006-01-01)

B01J23/46(2006-01-01)

B01J37/04(2006-01-01)

C07C227/06(2006-01-01)

C07C223/02(2006-01-01)

(21) (22)

Application

2006132505/04, 2005-03-09

(24)

Start date

2005-03-09

(22)

Actual filing date

2005-03-09

(45)

Published

2008-10-10

(72)

Inventor

Bao Tszjan'Bejlin Vladimir GenukkhGrin Derek DzhozefKhoug GarretKissel Uill'Jam SkottMarlatt Mark JudzhinPflam Derek EhndrjuU Kheh-Pin

(73)

Holder

Uorner-Lambert Kompani Lls

C-SYMMETRICAL BIOPHOSPHINE LIGANDS AND THEIR APPLICATION IN ASYMMETRICAL PREGABALINE SYNTHESIS Russian patent published in 2008 - IPC B01J31/24 C07F9/50 B01J23/46 B01J37/04 C07C227/06 C07C223/02

Abstract RU 2335342 C2

FIELD: chemistry.

SUBSTANCE: invention concerns C₁-symmetrical biophosphine ligands and respective catalysts and their application in asymmetrical syntheses, including enantioselective hydration of prochiral olefins for production of pharmaceutical compounds, including (S)-(+)-3-(aminomethyl)-5-methylhexane acid known as pregabaline and its structurally related compounds. The methods involve new prochiral catalysts or precatalysts for obtaining the catalysts, including chiral ligand, connected to rhodium by phosphor atoms, with chiral ligand structure represented by the formula 4 .

EFFECT: obtaining new catalysts for application in asymmetrical syntheses.

19 cl, 46 ex, 7 tbl,7 dwg

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RU 2 335 342 C2

Authors

Bao Tszjan'

Bejlin Vladimir Genukkh

Grin Derek Dzhozef

Khoug Garret

Kissel Uill'Jam Skott

Marlatt Mark Judzhin

Pflam Derek Ehndrju

U Kheh-Pin

Dates

2008-10-10—Published

2005-03-09—Filed