DERIVATIVES OF 10,10-DIALKYLPROSTANIC ACID USED FOR INTRAOCULAR DECOMPRESSION Russian patent published in 2008 - IPC A61K31/557 C07C401/00 

FIELD: medicine; pharmacology.

SUBSTANCE: invention describes application of derivatives of 10,10-dialkylprostanic acid as effective ophthalmic antihypertensive agents. Animal suffering from ocular hypertension or glaucoma is introduced with therapeutically effective amount of composition of general formula : where dotted line indicates presence or absence of bond, cross-hatch wedge designates α-configuration and solid triangle designates β-configuration; B is simple, double or triple covalent bond; n - 0-6; X - CH₂, S or O; Y is any pharmaceutically acceptable salt of group CO₂H, or group CO₂R, CONR₂, CONHCH₂CH₂OH, CON (CH₂CH₂OH)₂, CH₂OR, P(O)(OR)₂, CONRSO₂R, CONR₂ or of formula Ia; R - H, C_1-6alkyl or C_2-6alkenyl; R² and R³ represent C_1-6normal alkyl which can be same or another, and can be connected with each other so that to form ring including carbon atom to which both of them are connected.

EFFECT: invention provides higher efficiency of composition and method of treatment.

52 cl, 1 ex, 2 tbl, 8 dwg