FIELD: chemistry.
SUBSTANCE: improved is method of obtaining N-methyl-3-phenyl-3-(4-trifluorinemethylphenoxy) - propylamine hydrocloride, which is known under international non-patented name fluoxetin, used in medicine as highly efficient psychotropic preparation. Fluoxetin is obtained by interaction of 3-N-methylamino-1-phenyl-1-propanol with 4-chlorine benzotrifluoride in presence of sodium hydroxide with molar ratio 3-N-methylamino-1-phenyl-1-propanol: 4-chlorinebenzotrifluoride: sodium hydroxide, equal 1:2.3-2.5:8-10, respectively, in dimethylacetamide medium. Preferably process is carried out at temperature 120-125°C during 6 hours. Target product is extracted by toluol, from which by processing with concentrated hydrochloric acid, fluoxetin hydrochloride is isolated. Melting point 155°C (acetone). Method is suitable for industrial application in conditions of pharmacopical fluoxetin hydrochloride production.
EFFECT: method allows to use available raw material and simplifies isolation of target product.
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RU2331632C1 |
| 0 |
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SU1779244A3 | |
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|
RU2809762C2 |
| 0 |
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SU1781210A1 |
