FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to a method for producing levothyroxine of formula (II). Method includes iodination of a compound of formula (III) using sodium iodide and sodium hypochlorite in the presence of an aliphatic amine. Invention also relates to a method of producing levothyroxine sodium. (II), (III).
EFFECT: proposed method allows to obtain levothyroxine with high yield and purity.
10 cl, 5 ex
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Authors
Dates
2018-11-28—Published
2015-03-30—Filed