PROCESS FOR PREPARATION OF LEVOTHYROXINE AND SALTS THEREOF Russian patent published in 2018 - IPC C07C227/16 C07C229/36 

Abstract RU 2673540 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a method for producing levothyroxine of formula (II). Method includes iodination of a compound of formula (III) using sodium iodide and sodium hypochlorite in the presence of an aliphatic amine. Invention also relates to a method of producing levothyroxine sodium. (II), (III).

EFFECT: proposed method allows to obtain levothyroxine with high yield and purity.

10 cl, 5 ex

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RU 2 673 540 C2

Authors

Deshmukh, Swapnil, Sudhakar

Jain, Adinath, Murlidhar

Godbole, Himanshu, Madhav

Singh, Girij, Pal

Dixit, Dinesh, Dnyaneshwar

Dates

2018-11-28Published

2015-03-30Filed