ACIDIFIED INDANYLAMINES AND THEIR USE AS PHARMACEUTICAL PREPARATIONS Russian patent published in 2008 - IPC C07C233/64 C07C235/44 C07D307/78 C07D333/24 C07D209/04 C07D231/10 A61K31/38 A61K31/404 A61K31/34 C07D213/56 A61K31/415 A61K31/435 A61P9/00 A61K31/165 

FIELD: chemistry.

SUBSTANCE: in acidified indanylamines of general formula (I) R¹-R⁴ have values given in description, A represents CH₂, CHOH, B represents CH₂ and R⁵ represents aryl or heteroaryl group, possibly substituted with substituents, listed in description. Said compounds are useful in regulation of endothelial nitrogen oxide synthase (eNOS) and, therefore they can be useful for production of medications for treatment of stable and unstable angina pectoris, Prinzmetal's angina, acute coronary syndrome, impaired heart function, cardiac infarction, stroke, thrombosis, peripheral artery occlusive disease, endothelial dysfunction, atherosclerosis, hypertension, lung hypertension, symptomatic hypertension, renovascular hypertension, erectile dysfunction, diabetes or diabetes complications, nephropathy, retinopathy, limited memory function, limited learning ability.

EFFECT: increase of composition efficiency.

37 cl, 441 ex, 2 tbl