ACYLATED 6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTENYLAMINES AND THEIR USING AS PHARMACEUTICAL PREPARATIONS Russian patent published in 2007 - IPC C07C233/65 C07C233/74 C07C235/54 A61K31/166 A61P9/00

Abstract RU 2301797 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes acylated 6,7,8,9-tetrahydro-5H-benzocycloheptenylamines of the general formula (I): wherein R¹ and R⁴ mean independently hydrogen atom (H), (C₁-C₁₀)-alkyl monosubstituted with fluorine atom (F); R² and R³ mean independently H and (C₁-C₁₀)-alkyl; A means -CH, -CHOH; each among B, C and D means -CH₂; R⁵ means possibly substituted phenyl or group Hetar. Also, invention describes method for synthesis of indicated compounds and a pharmaceutical preparation designated for stimulation of expression of endothelial NO-synthase. Nitrogen oxide (NO) released by endothelial tissue displays important significance in function of some main mechanisms of cardiovascular system. Nitrogen oxide exerts the vasodilating effect and inhibits platelets aggregation, adhesion of leukocytes to endothelial tissue and proliferation of smooth muscle cells in internal envelope of blood vessels.

EFFECT: valuable medicinal properties of compounds and pharmaceutical preparations.

16 cl, 1 tbl, 152 ex

Similar patents RU2301797C2

Title	Year	Author	Number
BICYCLIC PYRIDINE DERIVATIVES USEFUL AS FATTY ACID BINDING PROTEIN (FABP) 4 AND / OR 5 INHIBITOR	2013	Byuttelmann Bernd Konte Aureliya Kyune Kholger Kun Bernd Najdkhart Verner Obst Zander Ulrike Rikhter Khans	RU2648247C2
ACIDYLATED HETEROARYLCONDENSED CYCLOALKENYLAMINES AND THEIR USE AS PHARMACEUTICAL AGENTS	2003	Shtrobel' Khartmut Vol'Fart Paulus	RU2338743C2
ACIDIFIED INDANYLAMINES AND THEIR USE AS PHARMACEUTICAL PREPARATIONS	2002	Shtrobel' Khartmut Vol'Fart Paulus Safarova Alena Val'Zer Armin Suzuki Teri Dkharanipragada Ramalinga M. Shenafinger Karl	RU2339614C2
PHARMACEUTICAL AGENT CONTAINING INHIBITOR OF SODIUM-DEPENDENT PHOSPHATE CARRIER	2015	Okhtake Esikhito Okamoto Naoki Ono Esiyuki Kasivagi Khirotaka Kimbara Atsusi Kharada Takeo Khori Nobuyuki Murata Esikhisa Tatibana Kadzutaka Tanaka Sota Nomura Keniti Ide Mitsuaki Midzuguti Ejsaku Itida Yasukhiro Okhtomo Suiti Khoriba Naosi	RU2740008C2
PHARMACEUTICAL PRODUCT CONTAINING INHIBITOR OF SODIUM DEPENDENT PHOSPHATE CARRIER	2015	Ohtake Yoshihito Okamoto Naoki Ono Yoshiyuki Kashiwagi Hirotaka Kimbara Atsushi Harada Takeo Hori Nobuyuki Murata Yoshihisa Tachibana Kazutaka Tanaka Shota Nomura Kenichi Ide Mitsuaki Mizuguchi Eisaku Ichida Yasuhiro Ohtomo Shuichi Horiba Naoshi	RU2811864C1
CONDENSED PIRIMIDINE DERIVATIVE AND PHARMACEUTICS WITH CRF RELATED ACTIVITY	2004	O`Jang Kaund Shenfel'D Rajan Krejg	RU2328497C2
NOVEL DERIVATIVES OF INDOLE-2,3-DIONE-3-OXIME	1997	Vot'En Frank Drajer Jorgen	RU2190612C2
PYRAZINE-2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS	2006	Eshke Georg Kol'Tsevski Sabina Porter Richard Kh'Ju Filip Viejra Ehrik	RU2407739C2
NOVEL CLASS OF SELECTIVE AGONISTS OF SOMATOSTATIN RECEPTORS	2014	Kazjulkin Denis Nikolaevich Aksenova Elena Aleksandrovna Skrabeliskaja Ekaterina Igorevna Moskalchuk Tatjana Viktorovna	RU2603962C2
ANTIVIRAL REMEDIES FOR TREATMENT AND PREVENTION OF HIV INFECTION	2021	Kurkin Aleksandr Vitalevich Manasova Ekaterina Vladimirovna Kazyulkin Denis Nikolaevich Ivanov Vladimir Nikolaevich Shurygin Mikhail Gennadevich	RU2780103C1

RU 2 301 797 C2

Authors

Shtrobel' Khartmut

Vol'Fart Paulus

Dates

2007-06-27—Published

2002-02-12—Filed