ACIDYLATED HETEROARYLCONDENSED CYCLOALKENYLAMINES AND THEIR USE AS PHARMACEUTICAL AGENTS Russian patent published in 2008 - IPC C07D401/12 C07D403/12 C07D409/12 A61K31/435 

FIELD: chemistry.

SUBSTANCE: invention pertains to acidylated heteroarylcondensed cycloalkenylamines with formula I in any of their stereoisomeric form or in form of their mixtures in any ratio, or their pharmaceutical salts, where in formula I: ring A represents an aromatic 6-member ring, containing 1 nitrogen atom, or a 5-member aromatic ring, containing 1 sulphur atom; one or two of R¹, R², R³ and R⁴ is independently chosen from a group consisting of hydrogen, halogen or C₁-C₄-alkyl, and the other R¹, R², R³ and R⁴ represent hydrogen; R⁵ represents an Ar group or Hetar group. Description is also given of a pharmaceutical composition based on compound with formula I and use of the latter.

EFFECT: regulation of the expression of the enzyme endothelial NO-synthesis.

10 cl, 31 ex