FIELD: chemistry.
SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 
, where: R1 is an aminogroup substitute selected out of optionally substituted C1-C5alkyl; R2 i is one or several same or different substitutes selected out of hydrogen, halogen, C1-C3 alkyl, CF3; Ar is phenyl or 5-6-member heterocycle containing 1-2 nitrogen or sulphur atoms in the cycle, unsubstituted or substituted by halogen, C1-C5alkyl, C1-C5alkoxy, substituted aminogroup or trifluormethyl; W is CH2 group optionally substituted CH2CH2 group or optionally substituted CH=CH group.
EFFECT: enhanced antiallergic and autoimmune effect.
4 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-b]INDOLES, METHOD OF PRODUCTION AND APPLICATION THEREOF | 2007 |
|
RU2334747C1 |
| LIGANDS OF ALPHA-ADRENOCEPTORS, DOPAMINE, HISTAMINE, IMIDAZOLINE AND SEROTONIN RECEPTORS AND USE THEREOF | 2008 |
|
RU2407744C2 |
| SUBSTITUTED 2,3,4,5-TETRAHYDRO-1N-PYRIDO[4,3-b]INDOLES, METHOD OF OBTAINING THEM AND USE | 2007 |
|
RU2338745C1 |
| AGENT FOR NEUTRALISING TOXIC ACTION OF TUMOUR NECROSIS FACTOR ON BASIS OF HYDRATED PYRIDO(4,3-b)INDOLES, PHARMACOLOGICAL AGENT ON ITS BASIS AND METHOD OF TREATING AUTOIMMUNE DISEASE ON BASIS OF NEUTRALISING TOXIC ACTION OF TUMOUR NECROSIS FACTOR | 2012 |
|
RU2477131C1 |
| SUBSTITUTED 8-SULPHONYL-2,3,4,5-TETRAHYDRO-1H-GAMMA-CARBOLINES, LIGANDS, PHARMACEUTICAL COMPOSITION, SYNTHESIS METHOD AND USE THEREOF | 2009 |
|
RU2404180C1 |
| DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT | 1995 |
|
RU2140417C1 |
| METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA WITH USING NEUROLEPTIC COMBINED THERAPY | 2007 |
|
RU2508096C2 |
| METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA WITH USING ATYPICAL NEUROLEPTIC COMBINED THERAPY | 2007 |
|
RU2508106C2 |
| TETRAHYDRO-PYRAZOLO[1,5-a]PYRIDO-PYRIMIDINES - SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS | 2008 |
|
RU2391343C1 |
| NORADRENERGIC AND SPECIFICALLY SEROTONERGIC ANXIOLYTIC AND ANTIDEPRESSANT, ITS PRODUCTION AND APPLICATION METHOD | 2020 |
|
RU2775772C2 |
