TETRAHYDRO-PYRAZOLO[1,5-a]PYRIDO-PYRIMIDINES - SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS Russian patent published in 2010 - IPC C07D471/14 A61K31/519 A61P25/28 A61P25/18 A61P25/24 A61P3/06 

FIELD: chemistry.

SUBSTANCE: present invention relates to serotonin 5-HT₆ receptor antagonists - new substituted 3-sulphonyl-6,7,8,9-tetrahydro-pyrazolo[1,5-a]pyrido[4,3-e]pyrimidines of formula and substituted 3-sulphonyl-5,6,7,8-tetrahydro-pyrazolo[1,5-a]pyrido[4,3-c1]pyrimidines of general formula 2, a medicinal base and pharmaceutical compositions containing the medicinal base in form of the said compounds, as well as to a method of treating and preventing development of different conditions and diseases of the central nervous system of humans and warm-blooded animals. In formulae and Ar is phenyl which is optionally substituted with halogen atoms, or a 6-member heteroaryl which contains a nitrogen atom in the ring; R¹ is a hydrogen atom, C₁-C₃alkyl, hydroxy C₁-C₃alkyloxy group, C₁-C₃alkylsulphanyl group; R² is a hydrogen atom or C₁-C₃alkyl, R³ is a hydrogen atom optionally substituted C₁-C₃alkyl or tert-butyloxycarbonyl.

EFFECT: obtaining compounds for preventing development of different conditions and diseases of the central nervous system of humans and warm-blooded animals.

16 cl, 3 tbl, 1 dwg, 10 ex