VEGETATIVE THYMIDINE KINASES AND THEIR APPLICATION Russian patent published in 2008 - IPC C12N9/12 

FIELD: medicine, microbiology.

SUBSTANCE: invention concerns biotechnology. The pharmaceutical composition, possessing thymidine kinase activity containing the allocated enzyme vegetative thymidine kinase or a polynucleotide coding it as the active beginning is described. The method of sensibilisation of a cell to a promedicine is revealed. The method of phosphorylation of nucleoside analogue-monophosphate is offered. The method of inhibition of the pathogenic agent in an organism of a warm-blooded animal is opened. The method of control or updating of growth of a plant is described. The agent including nucleoside analogue and thymidine kinase, or the gene coding specified obtained from plant thymidine kinase, or the vector including the specified gene, coding specified obtained from a plant thymidine kinase, in the form of a combination for simultaneous, separate or consecutive introduction is offered at cancer treatment. Described new thymidine kinases, received of a pine or rock cress. The given invention allows receiving new vegetative thymidine kinase, useful to transformation of nucleoside analogues in toxic substances, and useful to transformation nucleoside analogues in hydrophosphates, and hydrophosphates of nucleoside analogues in corresponding diphosphates.

EFFECT: obtaining of new vegetative thymidine kinases, useful to transformation of nucleoside analogues in toxic substances and for transformation of nucleoside analogues in hydrophosphates, and hydrophosphates of nucleoside analogues in corresponding diphosphates.

33 cl, 6 ex, 9 tbl, 2 dwg