2-IMIDAZOBENZOTHIAZOLES AS LIGANDS OF ADENOSINE RECEPTOR Russian patent published in 2008 - IPC C07D417/04 C07D417/14 C07D471/04 C07D491/04 C07D487/04 A61K31/428 A61P25/00 

FIELD: chemistry.

SUBSTANCE: in general formula I

R¹ is phenyl or 5-6-member heterocycle, containing one N atom and/or one O atom; R² is imidazole or annelated imidazole, selected from group, including a), b), c), d) and e); and R³ stands for hydrogen, phenyl, 2,3-dihydrobenzo[1,4]dioxin-6-yl, benzo[b]thiophen-3-yl, 3-methylbenzo[b] thiophen-2-yl, thiophen-2-yl or thiophen-2-ylmethyl, R⁴ is hydrogen or lower alkyl, R⁵ is hydrogen, lower alkyl, halogen, morpholinyl, -NR'R", piperydinyl, optionally substituted with hydroxy-group, or is pyrrolidin-1-yl; R⁶ is hydrogen or -(CH₂)_nO-lower alkyl, R⁷ is hydrogen, -C(O)O-lower alkyl, -C(O)-C₆H₄-halogen, -C(O)-C₆H₄-lower alkyl, -C(O)-lower alkyl, -C(O)-cycloalkyl, -C(O)-NR'R", -C(O)-(CH₂)_nO-lower alkyl, -S(O)₂-lower alkyl, -(CH₂)_nO-lower alkyl, -C(O)-pyridin-4-yl, whose ring can contain as substituents lower alkyl, halogen-lower alkyl or pyrrolidin-1-ylmethyl or is -(CH₂)_n-C(O)-NR'R"; R'/R" independently on each other stand for hydrogen, lower alkyl or -(CH₂)_n-tetrahydropyran-4-yl, X is -CH₂-, -NR'''- or -O-; R''' is hydrogen, -C(O)-lower alkyl, -C(O)O-lower alkyl, -C(O)-C₆H₄CH₃ or benzyl; n is 1 or 2.

EFFECT: increase of composition and treatment method efficiency.

14 cl, 56 ex