FIELD: medicine; pharmacology.
SUBSTANCE: new annelated asaheterocycles include pyrimidine fragment of general formula I in the form of free bases or pharmaceutically acceptable salts. Compounds of this invention possess properties of PI3 kinase inhibitors. In general formula I 
X represents oxygen atom or sulphur atom; Z represents oxygen atom, R1 represents hydrogen atom or optionally substituted C1-C6alkyl, or Z represents nitrogen atom together with bound carbon atom forming through Z and R1 optionally substituted annelated imidazoline cycle; R2 represents optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted phenyl, possibly annelated with 5-6-term heterocyclyl containing heteroatoms chosen from oxygen and nitrogen, optionally substituted 5-6-term heterocyclyl containing heteroatoms chosen from nitrogen, oxygen and/or sulphur, possibly annelated with phenyl ring. Invention also concerns method of production of compounds, pharmaceutical compositions and medical products.
EFFECT: effective application for preparation of medical products for oncologic therapy.
14 cl, 3 dwg, 1 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANNELATED AZAHETEROCYCLIC AMIDES, WHICH INCLUDE PYRIMIDINE FRAGMENT, METHOD OF OBTAINING AND THEIR APPLICATION | 2007 |
|
RU2345996C1 |
| SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHOD OF PRODUCING SAID COMPOUNDS AND USE | 2008 |
|
RU2378278C2 |
| SUBSTITUTED 4-SULPHONYL-PYRAZOLES AND 3-SULPHONYL-PYRAZOLO[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT AND METHOD OF OBTAINING THEM | 2008 |
|
RU2369600C1 |
| FURO- AND THIENO[2,3-b]-QUINOLINE-2-CARBOXAMIDES, METHOD OF PRODUCTION AND ANTITUBERCULOUS ACTIVITY | 2008 |
|
RU2371444C1 |
| ACTIVE SUBCTANCES, PHARMACEUTICAL COMPOSITION, METHOD OF THEIR PRODUCTION AND APPLICATION | 2007 |
|
RU2332421C1 |
| SUBSTITUTED 3,5-DIAMINO-4-SULFONYL-PYRAZOLES AND 2-AMINO-3-SULFONYL-PYRAZOLO-[1,5-a]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT RECEPTORS, METHODS FOR THEIR PRODUCTION AND USE | 2008 |
|
RU2376291C1 |
| SUBSTITUTED ESTERS OF 1H-INDOL-3-CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION, METHOD FOR THEIR PREPARING AND USING | 2006 |
|
RU2323210C9 |
| LIGANDS OF 5-HT RECEPTORS, PHARMACEUTICAL FORMULATION, PRODUCTION METHOD AND MEDICAL PRODUCT | 2006 |
|
RU2329044C1 |
| SUBSTITUTED ETHERS OF 5-HYDROXY-1H-INDOL-3-CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINMENT AND APPLICATION | 2007 |
|
RU2344817C1 |
| SUBSTITUTED ESTERS OF 1,2,3,7-TETRAHYDROPYRROLO[3,2-f][1,3]BENZOXAZIN-5-CARBOXYLIC ACIDS, PHARMACEUTICAL COMPOSITION, METHOD FOR THEIR PREPARING (VARIANTS) AND USING | 2006 |
|
RU2323221C9 |
