LIGANDS OF 5-HT RECEPTORS, PHARMACEUTICAL FORMULATION, PRODUCTION METHOD AND MEDICAL PRODUCT Russian patent published in 2008 - IPC A61K31/437 A61K31/443 A61K31/4439 A61K31/444 A61K31/513 A61K31/52 A61K31/55 C07D487/04 C07D471/04 C07D473/08 A61P3/10 A61P25/00 A61P25/14 A61P25/16 A61P25/18 A61P25/26 A61P25/28 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to application as ligands of 5-NT₆ receptor azaheterocyclic compositions of general formula 1 or their racemates, or their optical isomers, or their pharmaceutically acceptable salts and/or hydrates , where R² and R³ independently represent substitute of amides chosen from hydrogen; substituted carbonyl; substituted aminocarbonyl; substituted aminothiocarbonyl; substituted sulphonyl; C₁-C₅-alkyl, optionally substituted with C₆-C₁₀-aryl, optionally substituted with heterocyclil, C₆-C₁₀-arylaminocarbonyl, C₆-C₁₀- arylaminothiocarbonyl, C₅-C₁₀-azaheteroaryl, optionally substituted with carboxyl, nitrile group; optionally substituted with aryl; R¹ _k are 1 to 3 independent substitutes to cyclic system chosen from hydrogen, optionally substituted C₁-C₅-alkyl, C₁-C₅-alkyloxy, C₁-C₅-alkenyl, C₁-C₅- alkenyl, halogen, trifluoromathyl, nitrile, carboxyl, optionally substituted heterocyclil, substituted sulphonyl, optionally substituted carboxyl; dashed line with accompanying continuous line () corresponds to single or double bond; n=1.2 or 3. Invention also concerns a pharmaceutical formulation, production method and tabletted, capsulated or injection medical product in pharmaceutically acceptable package.

EFFECT: agent has improved efficiency.

17 cl, 8 tbl, 5 ex, 1 dwg