SUBSTITUTED ETHERS OF 5-HYDROXY-1H-INDOL-3-CARBOXYLIC ACID, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINMENT AND APPLICATION Russian patent published in 2009 - IPC A61K31/405 A61K31/5377 A61K31/444 A61K31/4439 A61K31/506 A61K31/4725 A61K31/4155 A61K31/4178 C07D209/42 C07D401/14 C07D401/04 C07D403/04 C07D409/04 C07D413/04 A61P31/12 A61P31/16 A61P31/18 

FIELD: medicine; pharmacology.

SUBSTANCE: invention claims ethers of substituted 1H-indol-3-carboxylic acid of the general formula 1 or their pharmaceutically acceptable salts. Compounds can be applied as active substance for pharmaceutical compositions and for application of these compositions in production of medicine for virus disease prevention and treatment, especially for diseases caused by infection hepatitis viruses (HCV, HBV) and influenza A viruses. In the general formula 1 R¹ is aminogroup substitute selected out of hydrogen, optionally substituted inferior alkyl, optionally substituted C_3-6cycloalkyl, optionally substituted aryl selected out of phenyl, naphthyl or 5-6 member heteroaryl containing 1-2 heteroatoms selected out of nitrogen, oxygen and sulfur, and possibly condensed with benzene ring of optionally substituted heterocyclyl, which can be optionally substituted 5-6-member heterocyclyl with 1-2 heteroatoms in heterocyclic ring selected out of nitrogen and oxygen; R² is alkyl substitute selected out of hydrogen, optionally substituted hydroxyl group, optionally substituted mercapto group, optionally substituted arylsulfinyl group; optionally substituted amino group, optionally substituted 5-6-member heterocyclyl containing 1-2 heteroatoms selected out of nitrogen, oxygen and sulfur; R³ is hydrogen or optionally substituted inferior alkyl; R₁ ⁴ and R₂ ⁴ are independently substitutes of cyclic system, selected out of hydrogen or halogen atom, cyano group, trifluoromethyl, optionally substituted phenyl or optionally substituted heterocyclyl which is an optionally substituted 5-6-member heterocyclyl with 1-2 heteroatoms in heterocyclic ring, selected out of nitrogen, oxygen or sulfur, possibly condensed with benzene ring.

EFFECT: improved efficiency of compositions.

15 cl, 3 tbl, 1 dwg, 6 ex