2-AMINOBENZOTHIAZOLS AS INVERS AGONIST OF CB RECEPTORS Russian patent published in 2009 - IPC C07D277/82 A61K31/428 A61P3/04 

FIELD: chemistry.

SUBSTANCE: this invention refers to new compounds of formula (Ia) and to their pharmaceutically acceptable salts. Compounds of this invention are characterised by CB₁ receptor antagonist properties. In formula (Ia) , R¹ means phenyl independently mono-, di- or tri-substituted with haloid, (lower)alkoxy, (lower)alkyl, halogenated (lower)alkoxy or di(lower)alkylamino; R² means phenyl, independently mono-, di- or tri-substituted with haloid, halogenated (lower)alkyl, nitro or cyano; R³ means hydrogen, nitro, amino, -NHSO₂-R^3a or -NHCO-R^3b; R^3a means (lower)alkyl, di(lower)alkylamino, benzyl, phenyl or phenyl monosubstituted with (lower)alkyl; R^3b means benzyl or phenyl monosubstituted with (lower)alkyl.

EFFECT: application of compounds thereof as therapeutically active substance with CB₁ receptor agonist properties and to relevant pharmaceutical composition.

18 cl, 1 dwg, 5 tbl, 70 ex