BENZOTHIAZOLE INHIBITORS OF PROTEIN TYROSINE KINASES Russian patent published in 2003 - IPC

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to novel derivatives of benzothiazole of the general formula (I) or its salt where p = 1; X₁ and X₂ form in common = O; R₁ means hydrogen, halogen atom, alkyl, alkoxy; R₂ means hydrogen atom; R₃ means -Z₄-R₆, -Z₁₃-NR₇R₈ wherein Z₄ means -Z₁₁-C(O)-Z₁₂-, Z₁₁-C(O)-O-Z₁₂-; wherein Z₁₁ and Z₁₂ represent a direct bond or alkylene; Z₁₃ means -Z₁₁-C(O)-Z₁₂-; R₄ means hydrogen atom; R₅ means phenyl substituted with groups Z₁, Z₂, taken among alkyl, halogen atom, nitro, -OH, hydroxyalkyl, -C(O)Z₆, -C(O)OZ₆-Z₄-NZ₇Z₈, wherein Z₄ means a direct bond; biphenyl substituted with alkyl; naphthalinyl that can be optionally substituted with OH; quinolinyl substituted with alkyl; heterocycloalkoxy; Z₆ means alkyl that can be optionally substituted with group -Z₄-NZ₇Z₈, morpholinyl; Z₇, Z₈ each means independently alkyl; R₆ means alkyl optionally substituted with cyano, methoxy, phenyl, -Z₄-NZ₇Z₈ and so on; R₇ means hydrogen atom, alkyl; R₈ means alkyl optionally substituted with one or more substituent taken among OH, lower alkyl, alkynyl, -SZ₆, methoxy, -Z₄NZ₇Z₈; and so on. Invention provides preparing novel derivatives of benzothiazole. EFFECT: improved preparing method, valuable biochemical properties of compounds. 10 cl, 10 tbl, 466 ex