FIELD: chemistry.
SUBSTANCE: present invention relates to novel substituted 4(6)-bromine-5-hydroxy-1H-indol-3-yl acetic acids and their esters, their pharmaceutically acceptable salts and/or hydrates which have antiviral activity, particularly against influenza virus having general formula 
or 
: where: R1 is an amino group substitute selected from a hydrogen atom, C1-C5alkyl optionally substituted with a hydroxy group, mono- or di(C1-C5 alkyl)amino group; acyl which is benzoyl optionally substituted with a halogen; or sulphonyl which is (C1-C5alkyl)sulphonyl, phenylsulphonyl optionally substituted with a C1-C5alkyl group, phenyl-C1-C3 alkylsulphonyl, 6-member nitrogen-containing heteroarylsulphonyl; R2 is an alkyl substitute selected from a hydrogen atom, a halogen atom, hydroxyl, amino, mono-(C1-C5 alkyl)- or di(C1-C5 alkyl)amino group; R3 is hydrogen optionally substituted with C1-C5alkyl; R4 is a hydroxyl group substitute selected from a hydrogen atom, C1-C5alkyl, C1-C5acyl; R5 is cyclic system substitute selected from hydrogen or mono(C1-C5 alkyl)- or di(C1-C5 alkyl)aminomethylene group. The invention also relates to a focused library, a medicinal agent and a pharmaceutical composition.
EFFECT: obtaining of compounds with antiviral activity.
26 cl, 1 tbl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED PHENOXYACETIC ACIDS, THEIR ESTERS AND AMIDES CONTAINING 2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PYRIN-8-YL FRAGMENTS - A ADENOSINE RECEPTOR ANTAGONISTS AND USE THEREOF | 2011 |
|
RU2477726C1 |
| SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACIDS AND ESTERS THEREOF, ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT, METHOD OF TREATING VIRAL DISEASES | 2008 |
|
RU2397975C1 |
| HETEROCYCLYLSULFINIC ACIDS AND THEIR DERIVATIVES, FOCUSED LIBRARY AND PHARMACEUTICAL COMPOSITION | 2004 |
|
RU2263666C1 |
| SUBSTITUTED [1,2,4]TRIAZOLO[4,3-a]PYRIDINES, DEMONSTRATING PROPERTIES OF ANTAGONISTS OF ADENOSINE A2A RECEPTORS, AND THEIR APPLICATION | 2013 |
|
RU2534804C1 |
| SUBSTITUTED 1,3-DIETHYL-8-VINYL-7-METHYL-3,7-DIHYDROPURINE-2,6-DIONES - ANTAGONISTS OF ADENOSINE A RECEPTOR AND USE THEREOF | 2012 |
|
RU2480469C1 |
| AZAHETEROCYCLES COMPRISING FRAGMENT OF PIPERIDIN-2-YL- FOCUSED LIBRARIES AND PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2259364C1 |
| ANTIVIRAL ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT, METHOD OF TREATING VIRAL DISEASES | 2009 |
|
RU2407738C1 |
| ACTIVE SUBSTANCES, PHARMACEUTICAL COMPOSITION, METHOD OF OBTAINING AND APPLICATION | 2007 |
|
RU2338531C1 |
| SUBSTITUTED 2,3,4,5-TETRAHYDRO-1N-PYRIDO[4,3-b]INDOLES, METHOD OF OBTAINING THEM AND USE | 2007 |
|
RU2338745C1 |
| SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-a]PYRIMIDINE-2,6-DIAMINES, SEROTONIN 5-HT RECEPTOR ANTAGONISTS, METHODS OF PRODUCING AND USING SAID COMPOUNDS | 2010 |
|
RU2421456C1 |
