SUBSTITUTED 2-(5-HYDROXY-2-METHYL-1H-INDOL-3-YL)ACETIC ACIDS AND ESTERS THEREOF, ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT, METHOD OF TREATING VIRAL DISEASES Russian patent published in 2010 - IPC C07D209/32 C07D401/12 A61K31/405 A61K31/4045 A61P31/12 A61P31/16 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel substituted 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acids. The substituted 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acids of general formula 1 and their pharmaceutically acceptable salts and/or hydrates , where: R¹ is an amino group substitute selected from hydrogen; optionally substituted C₁-C₅ alkyl; optionally substituted C₁-C₅ alkylsulphonyl, optionally substituted arylsulphonyl or optionally substituted heterocyclylsulphonyl; acyl; R² is an alkyl substitute selected from hydrogen, substituted amino group, optionally substituted hydroxy group, substituted mercapto group, substituted alkylamino group; R³ is hydrogen, C₁-C₃ alkyl; R⁴ is a substitute selected from hydrogen, C₁-C₃ alkyl substituted with an amino group, optionally substituted with phenyl or heterocyclyl; R⁵ is one or more substitutes of the cyclic system selected from trifluoromethyl, carboxyl, alkyloxycarbonyl, possibly substituted aryl, heterocyclyl, substituted aminomethyl, cyano group, or R⁵ is hydrogen provided that when R¹ is a substitute selected from hydroxy-substituted C₁-C₃ alkyl, amino-substituted C₁-C₃ alkyl, and R², R³, R⁴ and R⁶ are as described above, or R² is an alkyl substitute selected from substituted amino group, optionally substituted hydroxy group, substituted mercapto group, substituted alkylamino group, and R¹, R³, R⁴ and R⁶ are as described above; or R⁵ is fluorine.

EFFECT: obtaining novel substituted 2-(5-hydroxy-2-methyl-1H-indol-3-yl)acetic acids which have antiviral activity, especially against the influenza virus and hepatitis C virus (HCV).

19 cl, 3 tbl, 20 ex