DIAMINOPYRROLO QUINAZOLINES DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS Russian patent published in 2009 - IPC C07D487/04 A61K31/517 A61P3/08 

FIELD: chemistry, pharmaceutics.

SUBSTANCE: invention relates to novel derivatives of diaminopyrrolo quinazoline of formula (I), which possess properties of protein tyrosine phosphatase PTP-1B inhibitors and can be used for reduction of glucose concentration in blood. In general formula (I) A stands for 5- or 6-member unsaturated or saturated hydrocarbon ring or 5- or 6-member unsaturated or saturated ring, which contains at least one heteroatom, selected from S, N or O, R₁ represents hydrogen or lower alkyl; Ra represents hydrogen,

,

,

,

or lower alkyl , R₁, Ra, Rb, R_c, Rd, Re, Rf are such as defined in invention formula.

EFFECT: obtaining derivatives of diaminopyrrolo quinazoline which possess properties of protein tyrosine phosphatase inhibitors.

32 cl, 5 dwg, 118 ex