NOVEL COMPOUND HAVING PARP INHIBITORY ACTIVITY Russian patent published in 2017 - IPC C07D487/04 A61K31/519 A61P27/02 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula 1 or pharmaceutically acceptable salts thereof, which posses PARP (poly(ADP-ribose)polymerase) inhibitor properties. Compounds can be used for prevention or therapy of posterior eye diseases. In formula (1) R¹ is a halogen atom; R² and R³ represent a hydrogen atom; R⁴ and R⁵ represent a hydrogen atom or a deuterium atom, or R⁴ and R⁵ can form an oxo group; R^a is a hydrogen atom or lower alkyl group, and R^b is a phenyl group or lower alkyl group, substituted with di-(lower alkyl) amino group, or 5-6-member heterocyclic group containing 1-2 heteroatoms in ring, selected from nitrogen atoms or nitrogen atom and an oxygen atom or a phenyl group, or 6-member nitrogen-containing heteroaryl group; R^a and R^b can be bonded with each other to form a 5-7-member nitrogen-containing heterocyclic ring, which can contain an additional nitrogen atom, optionally condensed with a benzene ring and optionally substituted with a group, selected from lower alkyl group, lower haloalkyl group, lower cycloalkyl group, lower cycloalkylcarbonyl group, lower alkoxycarbonyl group, low-cycloalkyl-lower alkyl group, di-(lower alkyl) amino group, di-(lower alkyl) amino-lower alkoxy group; phenyl group or phenyl-lower alkyl group, in each of which phenyl group can be substituted with 1–2 halogen atoms, hydroxy group, lower alkyl group, lower haloalkyl group, lower alkoxy group, C₁-C₂alkylenedioxy group; 5-6-member heterocyclic group, containing 1–2 heteroatoms in ring, selected from nitrogen atom, oxygen atom and sulphur atom, and/or nitrogen atom and oxygen atom, optionally substituted with a halogen atom and optionally condensed with a benzene ring or pyridine ring; ring A is a benzene ring or thiophenyl ring; and m is 0 or 1.

EFFECT: obtaining novel compounds.

12 cl, 61 tbl, 7 ex