METHOD OF TREATMENT OF LOCALLY ADVANCED BREAST CANCER Russian patent published in 2009 - IPC A61K35/18 A61K35/16 A61K31/196 A61K31/513 A61K31/675 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: method is implemented through sampling blood in amount 150 ml, producing plasma 50 ml and erythrocytic solution 100 ml, separating plasma into 2 bottles. The first bottle with autoplasma 30 ml is added with fluorouracil at 1000 mg/m² and cyclophosphan 1000 mg/m². The second bottle with autoplasma 20 ml is added with methotrexate 30-50 mg/m². The bottles are incubated at t 37°C within 20-30 minutes. Autoplasma preparations at first of the first bottle, then of the second bottle are introduced paratumourally and directly into tumour node towards lymph flow. Furacilin alcohol aseptic dressing is applied on the breast. Residual erythrocytic solution is added with leukovorin dosed 50 mg/m², incubated and introduced intravenously drop-by-drop; if necessary interstitial autoplasmochemotherapy procedure is performed again.

EFFECT: stabilised process and patients' transfer to resectable condition due to involution of tumour and regional metastases, reduced concurrent reactions and complications within treatment, reduced number of early relapses and remote metastases.

2 dwg, 1 ex