METHOD OF NEOADJUVANT CHEMOTHERAPY OF MAMMARY GLAND CANCER Russian patent published in 2008 - IPC A61K35/16 A61K33/14 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: from the first day of treatment centrifugate the autoblood obtained by vascular access in volume of 2400-2600 ml, 1600 ml of supernatant plasmas select in sterile vials, expose to filtrational detoxicating with use of filter F60S with rate of perfusion of 250-300 ml/minute. Then the obtained albuminous concentrate of autoplasma in volume 700-800 ml place in sterile vials in the equal portions corresponding to number of planned introductions of cytostatics under the scheme. Vials contain in a refrigeration cabinet at t-20°C. At carrying out of polychemotherapy by cytostatics under the scheme, an albuminous concentrate defreeze at t +4°C, each antitumoral preparation plant in 10 ml of a normal saline solution, enter into a vial with an albuminous concentrate, incubate at t +37.0°C within not less than 30 minutes and reinfuse them intravenously driply, spend 1-2 courses of neoadjunt treatment.

EFFECT: increase of efficiency of treatment at the expense of transfer of patients in an operable condition; reduction of the sizes of a tumour and lymphonoduses and depression of toxicity of spent polychemotherapy.

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