8-HYDROXYQUINOLINE DERIVATIVES Russian patent published in 2009 - IPC C07D215/24 C07D215/26 C07D215/28 C07D215/48 C07D401/04 C07D401/12 C07D409/04 C07D417/12 C07D417/14 A61K31/47 A61K31/4709 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention concerns method of treatment, alleviation and/or prevention of neurological state, particularly neurodegenerative disorders, involving administration of effective quantity of compound with formula I: . Also invention concerns application of compound of the formula I as neurotherapeutical, neuroprotective or antimyloid agent, pharmaceutical or veterinary composition for treatment, alleviation and/or prevention of neurological states, and compounds of the formula I on the following additional terms: (b) if R³, R and R' are H, and R² is (CH₂)₂NR⁹R¹⁰, then both R⁹ and R¹⁰ are not ethyl or methyl; (c) if R³, R and R' are H, and R² is (CH₂)₂NR⁹R¹⁰, then both R⁹ and R¹⁰ are not hydrogen or ethyl; (d) if R³, R and R' are H, and R² is NR¹¹R¹², then both R¹¹ and R¹² are not hydrogen; (e) if R³, R and R' are H, and R² is COR⁶, then R⁶ is not H, OH or CH₂Cl; (f) if R³, R and R' are H, and R² is not CH₃ or CH₂Cl; (g) if R³, R and R' are H, and R² is HCNN R⁹R¹⁰, then both R⁹ and R¹⁰ are not H.

EFFECT: efficient treatment, alleviation and prevention of neurological state.

24 cl, 14 tbl, 21 ex, 14 dwg