METHOD AND COMPOSITION FOR STIMULATING NEUROGENESIS AND INHIBITING NEURON DEGENERATION Russian patent published in 2012 - IPC C07D243/08 C07D401/12 A61K31/551 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a pharmaceutical composition having activity for stimulating formation of nerve tissue and (or) inhibiting neuron degeneration, containing a compound of formula , where each R₁ is independently selected from a group consisting of H, F, CI, Br, R₇ and -O-R₇, where R₇ denotes substituted alkyl containing 1-6 carbon atoms or an aralkyl or aryl group containing 6-14 carbon atoms; R₂ is selected from O or S; R₃ is selected from alkyl containing 1-6 carbon atoms or an ether containing 1-6 carbon atoms and R₄ is selected from an aryl containing 6-14 carbon atoms, an aralkyl substituted with an aromatic group, substituted with a heteroatomatic group or substituted with a heteroaromatic-alkyl group, or R₄ is selected from a substituted 3-quinolinylmethyl, 2-pyridyl, 2-pyridylmethyl, 2- or 4-pyrimidinyl, benzo[1,3]dioxol-5-yl or benzoxazolyl. The invention also relates to methods of stimulating formation of nerve tissue and/or inhibiting neuron degeneration, based on use of said compounds and specific compounds.

EFFECT: novel compositions and methods containing compounds which are useful for stimulating formation of nerve tissue.

23 cl, 5 tbl, 3 ex