FIELD: pharmacology.
SUBSTANCE: invention relates to method of preliminary physical processing of clarithromycin, whose application results in such modification of technologically important physical properties of active substance which allows to obtain medicinal form with more stable profile of active substance release during all term of medication storage life in comparison with profile of release from similar composition but without preliminary processing. Claimed method includes moistening of clarithromicin or mixture of clarithromycin with other excipients with light solvent or mixture of solvents, in which clarithromycin solubility constitutes approximately less than 0.1 g/l, with further drying. Claimed invention also relates to pharmaceutical composition containing clarithromycin, processed in accordance with claimed method, and application of film covering which contains combination of low-molecular polymer representing cellulose ester, having viscosity approximately 6 mPa*s, and highly-molecular polymer, representing cellulose ester, which has viscosity approximately 15 mPa*s, for covering tablet cores, containing clarithromycin, processed in accordance with claimed method.
EFFECT: medicinal form with more stable profile of active substance release.
18 cl, 5 ex
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