6-AMINO-1H-INDAZOLE AND 4-AMINOBENZOFURAN COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS Russian patent published in 2009 - IPC C07D231/56 C07D307/83 C07D401/12 C07D405/14 C07D407/04 A61K31/343 A61K31/416 A61P25/28 A61P29/00 A61P37/08 

FIELD: chemistry.

SUBSTANCE: invention refers to new compounds of formula 1: where R¹ stands for cycloalkyl containing 3 to 10 carbon atoms, R² stands for alkyl containing 1 to 4 carbon atoms, R³ stands for pyridylmethyl, R⁴ stands for phenyl unsubstituted or substituted with carboxy-, cyanogroup or alkoxycarbonyl; or to its pharmaceutically acceptable salts provided the specified compounds is not 4-(2-chlor-4-methoxyphenyl)-5-methyl-2-[N-(1-propylindazole-6-yl)-N-propylamino]thiazole where optically active compound can be in the form of one of its separated enantiomers or their mixtures, including racemic mixtures, or to compounds of formula II: where R³ stands for hydrogen or pyridylmethyl, R⁴ stands for hydrogen or phenyl unsubstituted or substituted with carboxy-, cyanogroup, alkoxycarbonyl, tetrazole-5-yl or phenylsulphonyl aminocarbonyl; R⁷ stands for alkoxygroup containing 1 to 4 carbon atoms being branched or nonbranched; R⁸ stands for -CO-C_1-4- alkyl or dioxanyl, and at least one of R³ and R⁴ is different from hydrogen, or to its pharmaceutically acceptable salts where optically active compound can be in the form of one of its separated enantiomers or their mixtures, including racemic mixtures. Additionally, the invention refers to pharmaceutical enzyme PDE4, based on compounds of formula I and II and to their application for producing medical products for enzyme PDE4 inhibition in treatment of various diseases.

EFFECT: compound improvement.

35 cl, 11 ex