PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS Russian patent published in 2010 - IPC C07D231/12 C07D403/04 C07D405/04 C07D405/12 C07D405/14 C07D417/12 A61K31/415 A61K31/4439 A61K31/416 A61P25/18 A61P11/06 A61P37/08 A61P29/00 

FIELD: chemistry.

SUBSTANCE: proposed phosphodiesterase 4 inhibitors are characterised by formulae II, III, V, VI, where X is CH or N; L is a single bond, -(CH₂)_nCONH-, -(CH₂)_nCON(CH₂CH₃)-, (CH₂)_nSO₂, (CH₂)_nCO₂ or alkylene, optionally substituted oxo or hydroxy; n assumes values from 0 to 3; R¹ is optionally substituted alkyl; R³ - H, alkyl, cycloalkyl, alkoxyalkyl, optionally substituted phenyl, phenylalkyl, heterocyclyl, heterocyclylalkyl or cycloalkylalkyl; R⁴ and R⁵ represent alkyl; R⁶ - cycloalkyl, R⁷ is H; R⁸ is H, carboxy, alkoxycarbonyl, -CO-alkyl, optionally substituted alkyl.

EFFECT: new phosphodiesterase 4 inhibitors have improved properties.

55 cl, 30 ex