FIELD: pharmacology.
SUBSTANCE: claimed invention relates to compound of formula (I) 
in which m represents integer number, equal 1 or 2; R1 represents group, selected, in particular from phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, naphtyl, chinolinyl, isochinolinyl, benzisoxazolyl, tienopyridinyl, said group is possibly substituted with one or several groups of R3, similar or different from each other or by group R4, R2 represents group of general formula CHR5CONHR6, R3 represents halogen atom or one of the following groups: piano, nitro, C1-6-alkyl, C1-6-alkoxy, C1-6-trifluoralkyl, C1-6-trifluoralkoxy, benzyloxy, phenyloxy, R4 represents group, selected, in particular from phenyl, benzofuranyl, naphtyl; one orseveral groups R4 can by substituted with one or several groups R3, similar or different from each other; R5 represents hydrogen atom or C1-3-akyl group; R6 represents hydrogen atom or alkyl, C3-7-cycloalkyl or C3-7-cycloalkyl -C1-3-alkylene group; as base, salts of binding of acid, hydrate or solvate. Also invention relates to method of obtaining compound of formula I, its use as medicine and to based on it pharmacological composition.
EFFECT: novel derivatives of 1-pyperazine and 1-homopyperazincarboxilates, useful for prevention or treatment of pathology, in which endogen cannabinoids and/or any other substrates, metabolised by ferment FAAH, participate.
12 cl, 3 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ARYLOXYALKYLCARBAMATE DERIVATIVES, SYNTHESIS THEREOF AND USE IN THERAPY | 2005 |
|
RU2392269C2 |
| PIPERIDINE ALKYL CARBAMATE DERIVATIVES, PRODUCTION THEREOF AND USE THEREOF AS FAAH ENZYME INHIBITORS | 2005 |
|
RU2384569C2 |
| DERIVATIVES OF ARYL- AND HETEROARYLPIPERIDINECARBOXYLATES, THEIR PRODUCTION AND THEIR USE AS INHIBITORS OF FAAH FERMENT | 2005 |
|
RU2376305C2 |
| 5,6-BISARYL-2-PYRIDINE CARBOXAMIDE DERIVATIVES, METHOD FOR PREPARING AND USING THEM IN THERAPY AS RECEPTOR ANTAGONISTS | 2009 |
|
RU2497808C2 |
| IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLE[2,3-A]PYRIDINE DERIVATIVES | 2000 |
|
RU2248976C2 |
| N-[(1H-PYRAZOL-1-YL) ARYL]-1H-INDOLE OR 1H-INDAZOLE-3-CARBOXAMIDE DERIVATIVES, PRODUCING AND USING THEM AS P2Y12 ANTAGONISTS | 2011 |
|
RU2572593C2 |
| HETEROARYLALKYLCARBAMATE DERIVATIVES, THEIR OBTAINING AND THEIR APPLICATION AS ENZYME FAAH INHIBITORS | 2005 |
|
RU2364586C2 |
| DERIVATIVES OF ALKYLPIPERAZINE- AND ALKYLHOMOPIPERAZINECARBOXYLATES, OBTAINING THEM AND THEIR USE AS FERMENT FAAH INHIBITORS | 2005 |
|
RU2331637C2 |
| 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | 2007 |
|
RU2463292C2 |
| PHARMACEUTICAL AGENT CONTAINING INHIBITOR OF SODIUM-DEPENDENT PHOSPHATE CARRIER | 2015 |
|
RU2740008C2 |
