2,4-PYRIMIDINDIAMINE COMPOUNDS HAVING EFFECT IN CASE OF AUTOIMMUNE DISORDERS Russian patent published in 2009 - IPC C07D413/14 C07D413/12 C07D417/12 A61K31/505 A61K31/506 A61P37/00 

FIELD: pharmacology.

SUBSTANCE: claimed invention relates to novel 2,4-pyridindiamine compounds of formula (1). In structural formula (I) L¹ is direct bond; L² is direct bond; R² is phenyl group, three times substituted with three groups R⁸; R⁴ is X represents N; Y is selected from group consisting of O, NH, S, SO and SO₂; Z is selected from group consisting of O, NH; on condition that if Y is selected from group consisting of NH, S, SO and SO₂, Z is not the same as Y; R⁵ is selected from group consisting from R⁶, halogen; each R⁶ is independently selected from group consisting of hydrogen, halogen; R⁸ is selected from group consisting from R^a, R^b, R^a substituted with one or several similar or different groups R^a or R^b, -OR^a, -O-CHR^aR^b; each R³⁵ independently on others is selected from group consisting of hydrogen and R³⁵, or in alternative case, two groups R³⁵, bound to one and the same carbon atom are taken together with formation of oxogroup (=O), and the remaining two groups R³⁵ each independently on each other are selected from group consisting from hydrogen and R⁸; each R^a is independently selected from group consisting of hydrogen, (C₁-C₆) alkyl, (C₃-C₈) cycloalkyl; each R^b is suitable group which is independently selected from group consisting of -OR^d, halogen, -CF₃, -C(O)NR^cR^c, and -OC(O)OR^d; each R^c is independently protective group or R^a; each R^d is independently protective group or R^a; each index m is independently integer number from 1 to 3.

EFFECT: novel compounds can be used for treatment or prevention of autoimmune diseases, for instance such as rheumatoid arthritis and/or related to it symptoms, systemic lupus erythematosus and/or related to it symptoms, as well as and/or related to it symptoms.

41 cl, 14 dwg, 1 ex