INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES Russian patent published in 2019 - IPC C07D401/14 C07D403/04 C07D403/14 C07D411/12 C07D413/14 C07D417/14 C07D471/04 A61K31/4178 A61K31/4439 A61K31/444 A61P25/24 A61P25/32 A61P25/34 A61P25/36 

FIELD: chemistry.

SUBSTANCE: present invention relates to indolin-2-one and 1,3-dihydro-pyrrolo[3,2-c]pyridine-2-one derivatives of general formula I, where Ar¹ is phenyl, pyridinyl or pyrimidinyl; Ar² is 5- or 6-member heteroaryl group containing 2 or 3 heteroatoms selected from N, O; R¹ is hydrogen, C_1-7-alkyl, halogen or C_1-7-alkoxy; R² is hydrogen or C_1-7-alkyl; R³ is hydrogen, C_1-7-alkyl, C_1-7-alkyl substituted with hydroxy, cycloalkyl, oxetan-3-yl, pyridinyl, imidazolyl, pyrazolyl, pyrimidinyl, where rings are optionally substituted with C_1-7-alkyl, or is -(CH₂)₃-S(O)₂-cyclopropyl; X is CH; n is 1 or 2; as well as pharmaceutically acceptable salts thereof. Invention also relates to specific compounds given in the patent claim.

EFFECT: treating certain central nervous system (CNS) disorders, which are schizophrenia symptoms, drug abuse, alcohol and drug addiction, obsessive-compulsive disorders, cognitive impairment, bipolar disorders, mood disorders, deep depression, therapeutically resistant depression, anxiety disorders, autism, Parkinson's disease, chronic pain, borderline personality disorder, sleep disorders, chronic fatigue syndrome, stiffness, anti-inflammatory effects in arthritis and imbalance.

18 cl, 2 tbl, 2 dwg, 132 ex