FIELD: chemistry.
SUBSTANCE: proposed is a chimeric or humanised monoclonal antibody against hepatocyte growth factor, produced from L2G7 antibody. Invented is a mouse antibody L2G7, produced by hybridoma ATCC PTA-5162, and the said hydbridoma. Described is a cell line, producing a chimeric or humanised monoclonal antibody against hepatocyte growth factor. Proposed is a pharmaceutical composition and a method of treating tumours based on the said antibody.
EFFECT: use of the invention provides for a neutralising antibody against hepatocyte growth factor, which can be used in treating human cancer.
7 cl, 12 dwg, 1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HUMANISED MONOCLONAL ANTIBODIES TO HEPATOCYTE GROWTH FACTOR | 2007 |
|
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|
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| ANTIBODIES RECOGNISING CARBOHYDRATE CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS, AND METHODS OF USING SUCH | 2007 |
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| ANTIBODIES AGAINST OX40 AND METHODS OF THEIR APPLICATION | 2012 |
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RU2562874C1 |
