METHOD OF INDUCED SPUTUM SAMPLING IN CHILDREN TO ESTIMATE SEVERITY AND NATURE OF BRONCHIAL MUCOSA INFLAMMATION Russian patent published in 2009 - IPC A61B10/00 G01N33/53 

FIELD: medicine; pulmonology and allergology.

SUBSTANCE: diagnostics and control of bronchial asthma in children and adults is ensured by measuring the standard initial index characterising state of bronchial patency. In children aged 5 and older, it represents the peak expiratory flow (PEF), while in children aged younger than 5 years, pulmonary auscultation is applied with evaluating the respiratory rate and bronchiospasm signs. Therefor, 5% sterile hypertonic solution is inhaled within accumulated time not more than 30 minutes until productive cough, complaints of anhelation, shortness of breath, thorax discomfort and vertigo are observed. After productive cough comes, a child should stand up, clear the throat and expectorate in a cup. Then a child should bend forward to make vibrating chest massage. If a child has started to expectorate good enough, inhalation procedure is terminated. Within 5 minutes, a child should clear the throat and expectorate periodically. If he does not know how to clear the throat and expectorate, vibrating massage of lateral and posterior chest is applied to stimulate coughing. Then pharynx secretion is sampled with using a medical electric suction machine in a cup of total volume at least 0.5 ml. For analysis, pieces of different sputum portions are taken, and 5 minutes from the beginning of inhalation or observance of complaints, PEF is measured in children aged 5 and older, while in younger children, pulmonary auscultation is applied. If the standard index is decreased by 20% and more and/or respiratory symptoms are observed again, a child should inhale short-acting β2-agonist in age-specific dose 100-200 mkg of Salbutamol. Then specified indices are measured once more. Provided normality is recovered, induction proceeds until productive cough is observed to sample some portions of sputum.

EFFECT: possibility to apply the method in childhood and simplified procedure of implementation.

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