METHOD OF TERBINAFINE PURIFICATION Russian patent published in 2009 - IPC C07C209/84 C07C211/30 

FIELD: chemistry.

SUBSTANCE: invention refers to the improved method of purification of terbinafine with formula (I) by distillation of the raw terbinafine base at decreased pressure and temperature in the range 110-170°C. The said distillation is carried out up to temperature which causes only limited product thermal destruction with its segregation in the form of free base or in the form of acid-addition salt. The distillation is preferably carried out at minimal time of increased temperature affect. For implementing of the said method it is desirable to use raw terbinafine obtained by the reaction of (E)-N-(3-halo-2-propenyl)-N-methyl-N-(1-naphtylmethyl)amine with 3,3-dimethyl-1-buthyn in presence of palladium and/or copper catalyst.

EFFECT: decrease of by-products and other admixtures content, increase of pure E-isomer yield.

9 cl, 1 dwg, 4 ex