FIELD: medicine.
SUBSTANCE: invention claims method of virus infection treatment in case of main tissue damage and main virus replication point located in liver (versions), relevant kit and combination. Method involves combined injection of therapeutically effective amount of interferon and riboflavin, with riboflavin administered in slow-release composition in daily dosage under 400 mg to maintain clinically effective ribavirin level in portal vein blood stream and in lower amount than required to reach clinically effective level in peripheral circulation. Method maintains clinically effective interferon level in portal system blood stream, yet it is lower than in peripheral circulation, and therefore maintains systemic interferon effect on the whole organism and selective ribavirin action in liver. Kit and combination can include andioxidiser or other membrane-stabilising medium.
EFFECT: stable virological effect for patient, reduced side effects.
30 cl, 2 ex
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Authors
Dates
2009-10-27—Published
2004-08-03—Filed