FIELD: biochemistry.
SUBSTANCE: invention relates to biochemistry. Described is a method of predicting response of a person infected with hepatitis C virus (HCV), to therapy with peginterferon alpha-2a, ribavirin and antiviral agent of direct action. Method comprises providing a sample from said person and identifying nucleotide present at single nucleotide polymorphism rs12148487. Presence of at least one A allele at rs12148487 in said subject indicates a higher likelihood of rapid virological response in two weeks (RVR2) achieved by said subject to said treatment relative to a subject that has two G alleles present at rs12148487.
EFFECT: invention enables to optimise treatment of patients with hepatitis C.
5 cl, 6 dwg, 1 ex
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