ARYLSULPHONYL BENZODIOXANES USED FOR MODULATING 5-HT6 RECEPTOR, 5-HT RECEPTOR OR BOTH Russian patent published in 2009 - IPC C07D319/20 C07D405/06 A61K31/357 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to new compounds of formula I: , where m ranges from 0 to 3, n ranges from 1 to 3, p is 0, Ar is phenyl, possibly substituted with C₁-C₆-alkyl, cycloalkyl, hydroxyalkyl, halogen, hydroxyl or cyano group, X is -O-,R¹ and R² each is independently hydrogen, C_1-6alkyl or C_1-6alkoxy-C_1-6alkyl or hydroxy-C_1-6alkyl, or one of R¹ and R² is hydrogen or C_1-6 alkyl, and the other is C_1-6alkylcarbonyl, C₃-C₈ cycloalkyl, aryl-C_1-6alkyl or hydroxyl, or R¹ and R² together with the nitrogen atom to which they are bonded can form a three- to seven-member ring, which can possibly contain an additional N heteroatom, or R¹ and R² together with the nitrogen atom to which they are bonded can form a guanidyl group, amidinyl group, carbamyl group or urea group, each R³ is independently C_1-6alkyl, R⁴ and R⁵ each is independently hydrogen or C_1-6alkyl; or their pharmaceutically acceptable salts, as well as pharmaceutical compositions containing these compounds.

EFFECT: invention can selectively modulate 5-HT receptors, including 5-HT₆ and 5-HT_2A receptors.

17 cl, 1 tbl, 6 ex