OXAZOLIDINONE DERIVATIVES Russian patent published in 2013 - IPC C07D413/14 C07D417/14 C07D471/04 C07D519/00 A61K31/536 A61K31/4704 A61K31/498 A61K31/4985 A61P31/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) where "----" denotes a bond or is absent; R¹ is a C_1-4alkoxy group or halogen; R^1b is H or C_1-3alkyl; U and V each independently denote CH or N; W is CH or N, or, if "----" is absent, W is CH₂ or NH; under the condition that at least one of U, V and W is CH or CH₂; A is -CH₂-CH(R²)-B-NH-* or -CH(R³)-CH₂-N(R⁴)-[CH₂]_m-*; where asterisks indicate a bond which binds said fragments through a CH₂-group with an oxazolidinone fragment; B is CH₂ or CO; and R² is hydrogen, OH or NH₂; R³ and R⁴ both denote hydrogen, or R³ and R⁴ together form a methylene bridge; m equals 0, 1 or 2; and G is a phenyl which is monosubstituted in position 3 or 4, or disubstituted in positions 3 and 4, where each substitute is independently selected from a group comprising C_1-4alkyl, C_1-3alkoxy group and halogen; or G is a group selected from groups G¹ and G⁵ where M is CH or N; Q' is S or O; Z¹ is N, Z² is CH and Z³ is CH; or Z¹ is CH, Z² is N and Z³ is CH or N; or Z¹ is CH, Z² is CR⁵ and Z³ is CH; or Z¹ is CH, Z² is CH and Z³ is N; and R⁵ is hydrogen or fluorine; or a pharmaceutically acceptable salt thereof. The compound of formula (I) or a pharmaceutically acceptable salt thereof are used as a medicinal agent for preventing or treating bacterial infections.

EFFECT: oxazolidinone derivatives used as antimicrobial agents.

15 cl, 2 tbl, 44 ex