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IPC

C07F5/06(2006-01-01)

C07C31/32(2006-01-01)

C07C29/70(2006-01-01)

(21) (22)

Application

2007139378/04, 2007-10-23

(24)

Start date

2007-10-23

(22)

Actual filing date

2007-10-23

(45)

Published

2009-11-20

(72)

Inventor

Dzhemilev Usein MemetovichTolstikov Aleksandr GenrikhovichD'Jakonov Vladimir Anatol'EvichKhalilov Leonard MukhibovichKhafizova Lejla OsmanovnaParfenova Ljudmila VjacheslavovnaIbragimov Askhat Gabdrakhmanovich

(73)

Holder

Institut Neftekhimii I Kataliza Ran

METHOD OF PRODUCING OPTICALLY ACTIVE (1R,2S,5R)-[[5-METHYL-2-(1-METHYLETHYL)CYCLOHEXYL]OXY] DICHLORALANE Russian patent published in 2009 - IPC C07F5/06 C07C31/32 C07C29/70

Abstract RU 2373212 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing optically active (1R,2R,5R)-[[5-methyl-2-(1-methylethyl)cyclohexyl]oxy]dichloralane of formula (1) , which can be used in fine organic synthesis and organometallic synthesis, particularly during production of enantiomerically pure products with high optical output. The method involves reacting (1R,2R,5R)-5-methyl-2-(1-methylethyl)cyclohexanol (D-menthol) with ethyl aluminium dichloride (EtAlCl₂), in molar ratio D-menthol : EtAlCl₂ equal to 10:(10÷14), in an argon atmosphere in a benzol medium at room temperature for 1 to 3 hours.

EFFECT: obtaining desired product with high output and regioselectivity.

1 tbl, 5 ex

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RU 2 373 212 C2

Authors

Dzhemilev Usein Memetovich

Tolstikov Aleksandr Genrikhovich

D'Jakonov Vladimir Anatol'Evich

Khalilov Leonard Mukhibovich

Khafizova Lejla Osmanovna

Parfenova Ljudmila Vjacheslavovna

Ibragimov Askhat Gabdrakhmanovich

Dates

2009-11-20—Published

2007-10-23—Filed