BENZYLPHENYLCYCLOHEXANE DERIVATIVES AND METHODS OF THEREOF APPLICATION Russian patent published in 2014 - IPC C07C35/21 C07C35/23 C07C35/50 C07C43/196 C07C43/215 C07C43/23 C07C43/253 C07C49/747 C07C69/25 C07C69/03 C07D317/64 A61K31/47 A61K31/75 A61K31/85 A61K31/122 A61K31/222 A61K31/357 A61P3/10 

Abstract RU 2505521 C2

FIELD: chemistry.

SUBSTANCE: claimed are compounds of general formula I , where values of radicals are given in description, possessing inhibiting action on sodium-dependent cotransporter of glucose SGLT. Present invention also claims pharmaceutical compositions, possessing inhibiting effect with respect to SGLT, and methods of obtaining said compounds and synthetic intermediates, as well as methods of obtaining said compounds per se or in combination with other therapeutic agents for treatment of diseases or states, subjected to impact of SGLT inhibition, for instance such disease as type 1 and 2 diabetes mellitus, hyperglucemia, diabetic complications, insulin resistance, metabolic syndrome, hyperinsulinemia, hypertension, hyperuricemia, obesity, edemas, dislipidemia, chronic heart failure and atherosclerosis.

EFFECT: increasing efficiency of application of derivatives.

21 cl, 23 ex, 1 tbl, 8 dwg

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RU 2 505 521 C2

Authors

Chehn' Juan'Vehj

Pehn Kun'

Chzhan Lili

Lv Binkhua

Sjuj Bajkhua

Dong Tszjatszja

Du Tszijuan'

Fehn Jan'

Sjuj Geh

Rajjappan Vasantakumar

Sid Brajan

Dates

2014-01-27Published

2008-12-11Filed