FIELD: medicine.
SUBSTANCE: invention refers to pharmaceutical industry, particularly to method for making resveratrol containing particles. The method for making thereof involves dispersion of resveratrol in organic copolymer of lactic and glycolic acids dissolved in methylene chloride, dispersion of prepared suspension in the external phase containing a surface-active substance, removals of the organic solvent, purification of the suspension by centrifugation or filtration, then lyophilisation of the prepared resveratrol particles. The method for making resveratrol containing particles involves addition of resveratrol and lecithin spirit in certain ratio to dissolved chitosan, removal of the organic solvent, and centrifugation of the suspension. Then supernatant containing particles is lyophilised. The composition containing resveratrol particles is made by any of specified methods and a pharmaceutically acceptable diluent or a filling compound.
EFFECT: making particles with prolonged release of resveratrol.
11 cl, 4 dwg, 5 ex
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