STABLE EMULSION FOR PARENTERAL INTRODUCTION OF BADLY SOLUBLE IN WATER COMPOUNDS, WHICH HAVE ANTI-TUMOR ACTIVITY, AND METHOD OF ITS OBTAINING Russian patent published in 2009 - IPC A61K31/337 A61K47/20 A61K47/34 A61K9/107 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to novel emulsion of "oil in water" type intended for parenteral introduction. Emulsion contains as active ingredient badly soluble in water compound with anti-tumor activity of taxans class, for example paclitaxel or docetaxel in concentration from 1 to 30 mg in 1 ml of emulsion. Emulsion also contains lecithin, effective quantity of antioxidant, stabiliser of emulsion, dimethylsulphoxide as co-solvent of active ingredient and lactide or glycolide co-polymer as active ingredient stabiliser. Emulsion contains particles with size less than 100 nm in quantity not less than 80%. Emulsion by invention is stable when diluted with infusion solutions.

EFFECT: invention removes defects, connected with presence in applied in therapy of tumor diseases compositions of co-solvents, which have toxic effect on human organism, as well as with instability of known emulsions in dilution with infusion solvents.

29 cl, 6 dwg, 1 tbl, 7 ex