POLYMER, ESSENTIALLY RADIOPAQUE PRODUCTS FOR EMBOLIC THERAPY Russian patent published in 2009 - IPC A61K51/00 A61K49/04 A61M36/14 C08G69/00 

Abstract RU 2373958 C2

FIELD: medicine.

SUBSTANCE: invention refers to chemical-pharmaceutical industry, particularly to polymer radiopaque products for embolic therapy. There is described embolic therapy product containing polymer of formula I:

where X=1 or Br; Y1 and Y2 = 0,1, 2, 3 or 4; f = 0-1; g = 0-1; f+g = 0-1; A is chosen from: , , , , ,

where R1 is H or alkyl group containing 1 to 18 carbon atoms and 0-5 heteroatoms, chosen from O and N; R3 is alkyl, aryl or alkylaryl group containing to 18 carbon atoms and 0-8 heteroatoms, chosen from O and N; B is aliphatic diol or polyalkylene glycol link; R and R2 are chosen from , where R7 - -CH=CH-, -CHJ1-CHJ2- and (-CH2-)a; R8 - -CH=CH-, -CHJ1-CHJ2- and (-CH2-)n; a and n = 0-8; J1 and J2 - Br or I; Q for R2 contains free carboxyl group and Q for each R is chosen from the group consisting of hydrogen and esters and amides of carboxylic acids where polymer contains enough halogen atoms to ensure radiopacity of the embolic therapy product.

EFFECT: invention possesses radiopacity properties thereby being biocompatible and biodegradable.

75 cl, 3 dwg, 3 tbl, 13 ex

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RU 2 373 958 C2

Authors

Brandom Donald K.

Shmid Ehrik

Zeltinger Dzhoan

Kon Dzhoakim B.

Bolikal Durgadas

Dates

2009-11-27Published

2004-09-27Filed