FIELD: chemistry.
SUBSTANCE: present invention relates to compounds of formula I, in free form of in form of a pharmaceutically acceptable salt. In formula I 
Ar is phenyl, substituted with a cyano group, R1 is phenyl, optionally substituted with one or more substitutes selected from halogen, cyano, C1-C8-alkoxy, carboxy, or R1 is furanylcarbonyl or phenylcarbonyl, or R1 is a 6-member N-heterocyclic group with one or two nitrogen atoms in the ring, optionally substituted with C1-C4-alkyl or C1-C4-alkoxy, R2 is hydrogen, and Y is a pyrimidinyl or pyridazinyl group, optionally substituted with at least one C1-C8-alkyl or di(C1-C8-alkyl)amino group.
EFFECT: invention relates to a pharmaceutical composition with antagonistic effect on A2b receptor, containing the disclosed compound as an active agent, to use of the disclosed compound in making a medicinal agent with antagonistic effect on A2b receptor and to use of the disclosed compound in making a medicinal agent for treating inflammatory or obstruction respiratory tract diseases.
6 cl, 16 ex
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